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Page 1
Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.
Nat Commun. 2020 Jun 23;11(1):3165. doi: 10.1038/s41467-020-16983-2.
Nat Commun. 2020.
PMID: 32576829
Free PMC article.
Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction.
Arnold LH, Groom HC, Kunzelmann S, Schwefel D, Caswell SJ, Ordonez P, Mann MC, Rueschenbaum S, Goldstone DC, Pennell S, Howell SA, Stoye JP, Webb M, Taylor IA, Bishop KN.
Arnold LH, et al.
PLoS Pathog. 2015 Oct 2;11(10):e1005194. doi: 10.1371/journal.ppat.1005194. eCollection 2015 Oct.
PLoS Pathog. 2015.
PMID: 26431200
Free PMC article.
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A continuous enzyme-coupled assay for triphosphohydrolase activity of HIV-1 restriction factor SAMHD1.
Arnold LH, Kunzelmann S, Webb MR, Taylor IA.
Arnold LH, et al.
Antimicrob Agents Chemother. 2015 Jan;59(1):186-92. doi: 10.1128/AAC.03903-14. Epub 2014 Oct 20.
Antimicrob Agents Chemother. 2015.
PMID: 25331707
Free PMC article.
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Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
McIntyre PJ, Collins PM, Vrzal L, Birchall K, Arnold LH, Mpamhanga C, Coombs PJ, Burgess SG, Richards MW, Winter A, Veverka V, Delft FV, Merritt A, Bayliss R.
McIntyre PJ, et al. Among authors: arnold lh.
ACS Chem Biol. 2017 Nov 17;12(11):2906-2914. doi: 10.1021/acschembio.7b00537. Epub 2017 Oct 30.
ACS Chem Biol. 2017.
PMID: 29045126
Free article.
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The interface between catalytic and hemopexin domains in matrix metalloproteinase-1 conceals a collagen binding exosite.
Arnold LH, Butt LE, Prior SH, Read CM, Fields GB, Pickford AR.
Arnold LH, et al.
J Biol Chem. 2011 Dec 30;286(52):45073-82. doi: 10.1074/jbc.M111.285213. Epub 2011 Oct 26.
J Biol Chem. 2011.
PMID: 22030392
Free PMC article.
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